Maude Cooper, Opal Tyler, and Ruby Montgomery are finally traveling to their dream destination, New York City, to celebrate their fiftieth birthdays.
While on vacation, they encounter many new sights and go on an adventure of a lifetime. Unfortunately, for Maude, Nadine Waters, her neighbor and life long rival, is also having the time of her life in New York City.
Is the Big Apple big enough for all of these personalities? Will the Stone Sisters make it back to Rhinestone in time to celebrate the Centennial? And why in the world is Ruby onstage dancing the disco with a Cher impersonator?